Expression of Snail and Twist compared with clinical and pathological parameters in patients with gastric cancer

Introduction : Epithelial-mesenchymal transition (EMT) is a process of change in the cellular phenotype from epithelial to mesenchymal morphology. The changes at level can explain great heterogeneity and plasticity different histological subtypes gastric carcinomas, which causes difficulties therapy. In it, cells reduce intercellular adhesion, crucial invasion metastasis carcinomas. Inhibition cell adhesion molecules such as E-cadherin known be influenced by number transcription factors, Snail Twist. Materials methods Our study aims examine immunohistochemically expression factors Twist 69 patients with cancer look for link between their clinical pathological characteristics. Results Positive was observed all cases studied us. We intensity immunohistochemical expression. There correlation degree differentiation tumor stage. poorly differentiated adenocarcinomas show diffuse strong nuclear staining. No found two markers, age, sex patients. Conclusions Evaluating markers may help assess progression prognosis. They used more accurate effective diagnosis precancerous lesions early because they are not expressed normal mucosa.